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If heroin is taken after the expiry of the foreseen deadline of implant effects, different situations are possible:

1. For some patients, despite the expiry of the foreseen deadline of implant effects, Naltrexone concentration in the blood remains pretty high and the blockade still exists. In such a case, the patient will feel nothing or weakened effect of heroin, which does not provide him the expected feelings. There are 10 % of such cases.

2. In most cases, after the expiration of Naltrexone effects, i.e. when Naltrexone is depleted and the implant no longer provides the blocking effects, the receptors, rested from heroin use are quantitatively multiplied and  their sensitivity qualitatively enhanced. Cells become extremely sensitive. Therefore even the smallest amount of heroin could cause overdose and even fatal outcome unexpectedly.

Restrain of using heroin at least a month after Naltrexone implant expires. Remember that there may be remains of Naltrexone in the system.

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