Vanoxerine treatment for stimulant dependence
Vanoxerine (GBR-12909) is a medication that acts on the dopamine transporter (DAT). It has been investigated in the context of stimulant dependence, including cocaine dependence, because of its effects on dopamine signalling.
Our addiction service provides medical assessments for patients seeking support with stimulant dependence. Where a specific treatment protocol is considered clinically appropriate, our doctors can discuss the available options following a thorough clinical evaluation.
How vanoxerine works
Vanoxerine has a high affinity for the dopamine transporter (DAT)—a protein involved in regulating dopamine signalling in the brain. By interacting with DAT, vanoxerine alters dopamine reuptake and has been investigated as a potential treatment approach for stimulant dependence.
Research into vanoxerine (GBR-12909) for cocaine dependence has included human clinical studies. However, clinical evidence remains limited, and vanoxerine is not established as a standard treatment. Because it is not suitable for everyone, any consideration of treatment requires a thorough, doctor-led clinical assessment.
Stimulant dependence (cocaine dependence) & vanoxerine
Stimulant dependence affects everyone differently—whether it involves cocaine, crack cocaine, amphetamines or other stimulant substances. Because no two people are the same, treatment should take into account the whole picture: your physical health, emotional well-being, previous experiences and personal goals.
That is why care begins with a private, doctor-led assessment. During your consultation, our team will discuss the available treatment options with you and help determine whether a specialised approach such as vanoxerine may be appropriate for your individual circumstances.
Vanoxerine injection: unlicensed status & clinical considerations
Long-acting vanoxerine injections have been investigated as a potential option for managing stimulant dependence. However, vanoxerine injection is not a standard licensed UK treatment for the treatment of cocaine dependence.
Where an unlicensed or off-label medicine is considered, the prescribing clinician will assess whether its use is appropriate for your individual needs, alongside established treatment options. This clinical evaluation covers:
- Evidence & Safety Profile: Reviewing the available research, potential risks and possible drug interactions.
- Individual Suitability: Assessing your general health, cardiovascular health and medical history.
- Monitoring & Aftercare: Establishing appropriate monitoring and ongoing follow-up care.
The regulatory status of any treatment, along with suitable alternatives, will be explained during your doctor-led assessment, helping you make a fully informed decision.
Safety & clinical monitoring
Because clinical evidence for vanoxerine remains limited, your safety is our priority. Any consideration of treatment requires careful medical assessment and appropriate doctor-led monitoring.
Before treatment is considered, your doctor will discuss:
- Known risks & uncertainties: A clear review of the available evidence, potential side effects and relevant health considerations.
- Treatment and monitoring: What to expect from treatment, including any health checks, follow-up appointments and ongoing monitoring that may be required.
- Alternative approaches: Established medical and psychological cocaine dependency treatment options, so you can make a fully informed decision about your care.
Important patient safety note
You should never increase the dose or use additional substances in an attempt to overcome the effects of treatment. Continuing to use stimulants can remain dangerous, particularly for your cardiovascular health, regardless of whether medication has been given to affect their effects.
Vanoxerine treatment at our clinic
Our clinic provides discreet, doctor-led assessments for people seeking medical support for stimulant dependence, including cocaine and amphetamine use.
If you are considering vanoxerine treatment (vanoxerine injections), a private consultation gives our doctor the opportunity to assess your health and discuss the treatment options available. Where a specialised or off-label treatment is considered appropriate, your doctor will explain its regulatory status, potential benefits, risks and available alternatives. Every treatment plan is considered on an individual basis.
Vanoxerine treatment pricing & fees
The cost of treatment depends on the approach recommended following your medical assessment, as well as any monitoring and follow-up that may be required.
For reference, the current price for a 3-month vanoxerine injection is £800.
Please contact our clinic team for:
- Current consultation and treatment pricing
- A clear breakdown of what is included in your treatment plan
- Information about medical monitoring and follow-up care
How to book an appointment
If you would like to discuss treatment options for cocaine or other stimulant dependence, you can arrange a confidential consultation with our clinical team.
During your consultation, our doctor will assess your individual circumstances, answer your questions and explain the treatment options that may be suitable for you.
Learn more about other treatment options for cocaine dependence and find out which approaches may be suitable for you following a medical assessment.
UK guidelines on clinical management of drug misuse and dependence
