Can Naltrexone make you feel  high?

No, it cannot.
No. Naltrexone does not produce a high. Even though it is chemically related to opioids, it works in the opposite way. It is a full opioid antagonist, which means that it blocks opioid effects entirely. You cannot get euphoric or narcotic effects from Naltrexone. Therefore, "Naltrexone high" is not possible.

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How Does Naltrexone Work?

Naltrexone attaches to the opioid receptors in your brain, preventing other opioids—like heroin, morphine, codeine, methadone, or buprenorphine—from binding.This means: You won’t feel the usual “high” if you relapse. The typical effects of opioids—euphoria, sedation, or pain relief—are blocked. Cravings for opioids and alcohol and cocaine are often reduced over time.

From all mentioned above, Naltrexone is not addictive, and you can stop taking it or renewing the implant abruptly, without any withdrawal symptoms. In this way, Naltrexone differs favorably from the substitution of Methadone, Suboxone, Substidol, which intake may not be interrupted.

What Happens to Cravings?

With consistent use, Naltrexone can help:

  • - Reduce cravings for drugs and alcohol
  • - Break the cycle of compulsive use
  • - Support long-term recovery by removing the psychological "reward" of using opiates

Is Naltrexone Addictive?

No, Naltrexone is not addictive.
Unlike opioid-based treatments such as methadone, Suboxone, or Substitol, Naltrexone:

  • - Does not cause physical dependence
  • - Can be discontinued abruptly, without withdrawal symptoms
  • - Offers a non-addictive alternative in opioid recovery programmes

Is "Naltrexone high" possible?


Naltrexone vs. Opioid Medications

Medications like methadone, Subutex, Suboxone, and OxyContin are sometimes used for opioid substitution therapy. However, they carry some risks:

- They can create stronger physical dependence than heroin itself.
- Abrupt cessation can cause severe withdrawals: pain, vomiting, diarrhea, insomnia, depression, agitation, and in rare cases, psychosis. Methadone withdrawal may last several weeks without medical supervision.

Naltrexone is different as it gives you freedom:

- No dependence
- There is no feeling "high
- No risk of overdose from Naltrexone itself
- Can be stopped at any time safely
- It helps maintain true abstinence by blocking the effects of opioids, making relapse far less rewarding both physically and psychologically.

While medications like methadone, Subutex, Suboxone, and OxyContin are used in opioid substitution therapy, they often come with a heavy cost:
They can lead to even greater physical dependence than heroin itself.

Stopping these medications abruptly can trigger intense and prolonged withdrawal symptoms.

For example, methadone withdrawal can last several weeks if not treated medically. Many former heroin users who once endured heroin withdrawal without medical support often find it impossible to withstand even two days without methadone or other long-acting opioids. Medical intervention is almost always required.


Long-Term Protection with Naltrexone Implants

For individuals committed to a life free from heroin or other opioids, long-acting subcutaneous Naltrexone implants provide powerful support.

These specially designed implants (e.g., Depone Naltrex-12, Pellet Naltrex):

  • -Deliver consistent therapeutic levels of Naltrexone
  • -Offer up to 12 months of continuous protection
  • -Reduce the risk of relapse and eliminate the need for daily dosing

They are ideal for patients seeking long-term stability, without the risks associated with opioid substitution therapies.


Conclusion - Is "Naltrexone high" real?

Your body is healing. The Naltrexone implant is working silently but powerfully to protect you.
Give it the support it needs. Rest, recover, and follow our implant followup guidelines carefully to ensure the success of your treatment. Remember: Naltrexone high isn't possible!

If you have any pain, swelling, fever, or unusual symptoms, contact our medical staff immediately.