Side effects and even complications of Naltrexone implants can occur in about 8% of cases. Primarily, it is the implant rejection as a foreign body. Especially, Magnesium stearate causes such a selfedefensive immune response of the organism. It must be said that Triamcinolone causes constriction of blood vessels and reduced blood flow in the implant area. All mentioned above can cause aseptic, allergic and non-purulent tissue reactions. This is manifested by swelling, itching, rash and redness. If such reactions are not stopped timely and they continue to develop, a small channel could be formed in a few days. Then a little opening in the implant area will ocure and tissue secretions leaking might appear from the wound. This tells us that the reaction has started a few days earlier which had to be stopped immediately. However, even if all this has already happened, the treatment can be very effective: anti-inflammatory medicines, anti-allergic medicaments, especially hormonal, plus antibiotics since the wound is leaking, which is an open door for infection. Consequently, the organism must be protected from possible infection. Antibiotics will be given for certain period of time. Then, usually, reaction of rejection will gradually withdraw and swelling and redness will pass. Wound will tighten up and the opening will close, so the person will carry his implant normally. It's important to promptly, immediately, from the very first day of the occurrence of some unconfrtable sensations, contact the doctor and start with preventive therapy in order to stop the allergic reaction. Besides the local reactions, a real allergy, a general reaction might occur. This happens extremely rarely and it gives the rash and itching on the skin, too. Besides these aseptic complications, suppurative-septic reactions might occur. For example, if a copy of the implant is placed, or storage sterility and transportation regulations are compromised, if the packaging is partially opened, or shelf life of the implant is expired, if the implant is placed by unqualified surgeon, if the septic and antiseptic rules are compromised during surgery or later bandaging, if the patient touches the stitches of the wound. Patients sometimes remove the bandage and scratch the wound which is categorically forbidden. However, if the infection of the wound region of the implant had occurred, it is necessary to contact a doctor immediately and implement antibacterial therapy. Proper bandaging and proper medications stop the suppurative-septic reaction and the condition is gradually normalized.